Loss of <scp>MEGF10</scp> Decreases the Number of Perisynaptic Schwann Cells and Innervation of Neuromuscular Junctions in Aging Mice
The data in this study suggest that MEGF10 in PSCs functions to maintain PSC number and NMJ innervation during aging. This study also suggests important roles for MEGF10 in mediating the clearance of axonal debris at NMJs following nerve injury.
Authors
- Gregorio Valdez (ORCID: https://orcid.org/0000-0002-0375-4532)
- Jeremy N. Kay (ORCID: https://orcid.org/0000-0001-6145-1604)
- Devin Juros (ORCID: https://orcid.org/0000-0003-1151-0738)
- Robert Louis Hastings (ORCID: https://orcid.org/0000-0003-3342-7441)
- Ariane Pendragon
Institutions
- Allen Institute for Brain Science (US)
- Duke University (US)
- Brown University (US)
Publication Details
- Journal
- Journal of the Peripheral Nervous System
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/jns.70014
- Citations
- 1
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke