Exceedingly high levels of tetracycline resistance in <i>Neisseria gonorrhoeae</i> in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021–2024—doxycycline post-exposure prophylaxis will unlikely imp
The exceedingly high levels of gonococcal tetracycline resistance (independent of resistance breakpoint used) in the eight WHO EGASP countries elucidate that doxycycline-PEP will unlikely significantly reduce the gonorrhoea cases in these countries. Furthermore, doxycycline-PEP might rapidly select for additional gonococcal strains with tetracycline resistance (low- and high-level) and MDR/XDR strains, i.e. because these strains are mostly resistant to tetracycline.
Authors
- Teodora Wi (ORCID: https://orcid.org/0000-0002-7640-9166)
- Manuel C Jamoralin
- Vichea Ouk (ORCID: https://orcid.org/0009-0006-5659-8402)
- Nhi Thi Uyen Pham (ORCID: https://orcid.org/0000-0002-3976-9963)
- Marietta L Lagrada (ORCID: https://orcid.org/0000-0001-8585-415X)
- Ismaël Maatouk (ORCID: https://orcid.org/0000-0003-1008-7413)
- Peter Kyambadde (ORCID: https://orcid.org/0000-0002-9606-218X)
- Porntip Paopang
- Natnaree Girdthep (ORCID: https://orcid.org/0000-0001-6888-2108)
- Jaywardeen Abad
- Robert G. Krysiak (ORCID: https://orcid.org/0000-0001-5454-2620)
- Thuy Thi Phan Nguyen
- E Müller (ORCID: https://orcid.org/0000-0002-9800-491X)
- Emmanuel Mande (ORCID: https://orcid.org/0000-0003-0587-8181)
- Phiona Vumbugwa (ORCID: https://orcid.org/0000-0002-0214-1267)
- Hao Trong Nguyen (ORCID: https://orcid.org/0000-0002-7732-0497)
- Daniel Golparian (ORCID: https://orcid.org/0000-0002-0688-2521)
- Lindy Gumede
- Le Huu Doanh (ORCID: https://orcid.org/0000-0002-9982-9905)
- Francis Kakooza (ORCID: https://orcid.org/0000-0003-4047-6620)
- Shuwen Deng
- Teguh Sarry Hartono (ORCID: https://orcid.org/0000-0001-9984-0285)
- Pongsathorn Sangprasert (ORCID: https://orcid.org/0009-0008-7470-8710)
- Sonia Sia (ORCID: https://orcid.org/0009-0005-2475-9577)
- Phạm Thị Làn (ORCID: https://orcid.org/0000-0002-0127-9328)
- Magnus Unemo (ORCID: https://orcid.org/0000-0003-1710-2081)
- Nguyễn Thị Thuỳ Vân (ORCID: https://orcid.org/0000-0002-6526-0175)
- Jaray Tongtoyai (ORCID: https://orcid.org/0000-0002-6929-6298)
- Rossaphorn Kittiyaowamarn (ORCID: https://orcid.org/0000-0001-9382-7776)
- Mitch Matoga (ORCID: https://orcid.org/0000-0002-6542-8193)
- Thitima Cherdtrakulkiat (ORCID: https://orcid.org/0000-0001-5006-6145)
- June M Gayeta (ORCID: https://orcid.org/0000-0001-6339-2476)
- Endang Lukitosari
- Vivi Setiawaty (ORCID: https://orcid.org/0000-0002-1196-7909)
- Nurhalina Afriana
- Dickson Tabajjwa (ORCID: https://orcid.org/0009-0001-3850-3637)
- Mot Virak
- Ni Luh Putu Pitawati
- Heng Li (ORCID: https://orcid.org/0000-0002-6666-0277)
- Phuong Thi Thanh Nguyen (ORCID: https://orcid.org/0000-0002-3357-7661)
- Hoa Quynh Pham (ORCID: https://orcid.org/0000-0001-6165-3628)
- Irving Hoffman (ORCID: https://orcid.org/0000-0003-0059-5991)
- Dumisile V. Maseko (ORCID: https://orcid.org/0000-0002-9707-9485)
- Susanne Jacobsson
- Pham Dieu Hoa
- Monica M Lahra
- Venessa Maseko
- Daniel Schröder
- Verawati Sulaiman
- Phal Kun Mom
- Maria Laurensia
- Martha Nakasi
Institutions
- National Health Laboratory Service (ZA)
- World Health Organization - Pakistan (PK)
- Ministry of Public Health (TH)
- Örebro University (SE)
- Research Institute for Tropical Medicine (PH)
- Ministry of Health (UG)
- National Institute of Public Health (KH)
- National Center for HIV/AIDS, Dermatology and STD (KH)
- HCMC Hospital of Dermato Venereology (VN)
- Infectious Diseases Institute (UG)
- Vietnam National Children's Hospital (VN)
- University College London (GB)
- Makerere University (UG)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1093/jac/dkaf066
- Citations
- 6
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 7.10