Vitamin D levels in Diabetic Nephropathy

Objective: This study aims to evaluate the levels of vitamin D in Newly Diagnosed Type 2 diabetics and in diabetics with nephropathy and to compare it with age matched healthy control. Method: Cross sectional study involving a total of 316 individuals in Bengaluru, India from the period of December 2022 to November 2024 were considered for the study. Fasting venous blood and 24 hour urine sample was collected from 316 individuals comprising 124 N.D. type 2 Diabetics , 92 Diabetics with nephropathy and 100 healthy individuals and analysed for Glycosylated Hemoglobin(HbA1c), serum creatinine , vitamin D and urinary Albumin along with their demographic details. Results: Age, gender had a statistical significance with diabetic nephropathy. There was significant decrease in the vitamin D levels only in Diabetics with nephropathy population compared to healthy and Newly Diagnosed type 2 Diabetics population although vitamin D levels in Newly Diagnosed Type 2 Diabetic population was lower than that of healthy population. Conclusion: Variations in Vitamin D levels in these three population can be a signal of progression of Type 2 Diabetes into Diabetic Nephropathy. Hence monitoring of Vitamin D helps in early detection of diabetic complications thus preventing it from progressing further.