Rapid synthesis of pomalidomide-conjugates in minutes <i>via</i> temperature elevation and delayed feeding
The synthesis of pomalidomide-conjugates, crucial intermediates for developing PROTACs, suffers from prolonged reaction times and extensive byproduct formation. Herein, we present a methodology that overcomes these limitations, achieving complete reaction within minutes while minimizing side products. By shortening the reaction timeframes, our method will facilitate the exploration of novel pomalidomide-based PROTACs.
Authors
- Siping Wei (ORCID: https://orcid.org/0000-0002-1084-8772)
- Li Chen (ORCID: https://orcid.org/0000-0003-2890-4370)
- Qiang Fu (ORCID: https://orcid.org/0000-0001-9993-8776)
- Yingying Jiang (ORCID: https://orcid.org/0000-0002-0788-8546)
- Lin Wang (ORCID: https://orcid.org/0000-0003-1219-7632)
- Hang Zhao (ORCID: https://orcid.org/0000-0001-5521-3597)
- Jun Wang (ORCID: https://orcid.org/0000-0003-0376-6071)
Institutions
- University of Nottingham Ningbo China (CN)
- Southwest Medical University (CN)
- Ningbo Science and Technology Bureau (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00611b
- Citations
- 1
- Primary Topic
- Dendrimers and Hyperbranched Polymers
- Type
- article
- Field-Weighted Citation Impact
- 0.61