Awareness of Aspirin’s Dual Role as an Anti-cancer Agent and Anti-thrombotic Agent and its Association with Medication Adherence to Low-Dose Aspirin: A Cross-Sectional Study

Abstract: Background: Aspirin is known to be an effective antithrombotic agent. Multiple studies have been studying its effect on cancer as colorectal cancer. Aim: This study aimed to measure the Awareness of Aspirin's Dual Function as an Anti-Cancer Agent and Anti-Thrombotic among Residents of the Makkah region in the Kingdom of Saudi Arabia. Methods: A cross-sectional study was conducted involving 490 participants from the Makkah region. Data collection was achieved through a self-reported online questionnaire and distributed via social media platforms from period of November 2024 until January 2025. Results: Over 340 of the participants in this research have bachelor's degrees. However, while investigating awareness regarding the preventative effect of aspirin's dual role, only 8.4% were aware. Moreover, in terms of assessing the adherence level, we only included 306 (62.4%) of the participants who reported taking aspirin. The majority of them showed low adherence levels. Conclusion: This study reveals a lack of awareness regarding of the knowledge abouts Aspirin as an Anti-Cancer and Anti-Thrombotic Agent among the residents of Makkah region, which appears to have an effect on medication adherence. Awareness promotion is essential to enhance public health outcomes. Keywords: Aspirin; Anticancer; Antithrombotic, Makkah, Adherence.