Association between periodontitis severity and prostate‐specific antigen levels using the NHANES data

Periodontitis is an inflammatory condition known to be associated with systemic health. This study aimed to investigate a potential association between periodontitis and prostate cancer, focusing on levels of prostate-specific antigen (PSA), a marker used in prostate cancer screening. Age, race, periodontitis severity, and open pocket percentage were significantly associated with total PSA levels. However, this increase did not significantly correlate with the defined PSA cutoff points of 2, 2.5, and 4. Additionally, calcium levels, osteoporosis, arthritis, and C-reactive protein levels as potential mediators did not significantly impact this relationship. Moreover, edentulous patients were significantly associated with higher odds of needing further treatment for prostate disease. Hence, while considering cases where periodontal disease may contribute to systemic prostate issues, implementing a dual-therapy strategy that addresses both the local inflammation as well as the systemic effects of periodontal disease might be a more effective approach in the management of these conditions.