Cover Feature: Endoplasmic Reticulum‐Targeting Delayed Fluorescent Probe for Dual‐mode Nitroreductase Sensing (Chem. Asian J. 6/2025)

The study highlights an innovative approach to developing a highly selective delayed fluorescent probe for the dual-mode detection of a cancer hallmark within the endoplasmic reticulum (ER, depicted as a greenish-blue structure). The ER-specific probe, designed for selective detection of nitroreductase (NTR, shown in orange), is initially in a non-fluorescent state (grey). Upon interacting with NTR, the probe activates, emitting green fluorescence and long-lived emission, enabling intracellular detection through luminescence and time-resolved imaging modes symbolized by clock icons. More details can be found in article number e202401226 by Abhijit Patra and co-workers.