Recovery of Antibody Immunity After a Resurgence of Respiratory Syncytial Virus Infections
Longitudinal measurements of respiratory syncytial virus (RSV) immunity over 4 winter seasons reveal that viral neutralization titers, RSV prefusion F protein (pre-F)-specific immunoglobulin M and immunoglobulin G (IgG) levels, and RSV antibody-dependent cellular phagocytosis function gradually returned to prepandemic levels in female healthcare and school workers of childbearing age after 2 winter seasons, following the resurgence of RSV cases in the Vancouver metropolitan region (British Columbia, Canada). In contrast, pre-F IgG avidity profiles remained unchanged. These findings support the notion that repeated viral infections are necessary to maintain high RSV antibody levels in the population.
Authors
- Frederic Reicherz
- Bahaa Abu-Raya (ORCID: https://orcid.org/0000-0002-3528-0343)
- Agatha N. Jassem (ORCID: https://orcid.org/0000-0002-4128-2919)
- Marina Viñeta Paramo (ORCID: https://orcid.org/0000-0003-1096-3831)
- Pascal M. Lavoie (ORCID: https://orcid.org/0000-0002-2205-0362)
- Liam Golding (ORCID: https://orcid.org/0000-0002-8851-8052)
- Allison W. Watts (ORCID: https://orcid.org/0000-0001-7874-7030)
- Sirui Li
- Jeffrey N. Bone (ORCID: https://orcid.org/0000-0001-7704-1677)
- A Lavoie
Institutions
- University of British Columbia (CA)
- Witten/Herdecke University (DE)
- BC Centre for Disease Control (CA)
- BC Children's Hospital (CA)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1093/infdis/jiaf101
- Citations
- 7
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 9.48