High expression and regulatory mechanisms of ANGPT1 and HOXA3 in acute myeloid leukemia
ANGPT1 and HOXA3 are highly expressed in AML, and knocking them down can promote apoptosis and senescence in leukemia cells. They exhibit a mutual regulatory relationship, forming a positive feedback loop. These findings contribute to a better understanding of the functional roles and regulatory mechanisms of ANGPT1 and HOXA3, and provide new scientific evidence for the treatment and prognosis improvement of AML patients.
Authors
- Yongcai Wang
- Xiaoli Wu (ORCID: https://orcid.org/0000-0001-5587-2146)
- Xuan Fan
- Baoxi Zhang (ORCID: https://orcid.org/0000-0001-7462-7592)
- Na Liu (ORCID: https://orcid.org/0009-0002-0017-2307)
- Huifeng Zhang (ORCID: https://orcid.org/0009-0005-3499-7325)
- Wen-Xiao Wen
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Bulletin du Cancer
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.bulcan.2025.01.014
- Citations
- 3
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 5.31