Osteosarcoma Exosome Priming of Primary Human Lung Fibroblasts Induces an Immune Modulatory and Protumorigenic Phenotype
These findings provide a critical first step in characterizing the capacity of OS-derived exosomes to reprogram primary LFs toward a tumor-promoting inflammatory phenotype in vitro, offering novel molecular targets for the modulation of fibroblasts in the lung microenvironment as potential therapeutic strategies to prevent OS metastasis.
Authors
- Kathryn E. Cronise (ORCID: https://orcid.org/0000-0003-3224-1469)
- Daniel P. Regan (ORCID: https://orcid.org/0000-0002-3148-1332)
- Laurel A. Haines (ORCID: https://orcid.org/0000-0002-8410-248X)
- Carina P. Easton (ORCID: https://orcid.org/0000-0001-6689-8560)
- Sunetra Das (ORCID: https://orcid.org/0000-0002-8941-1468)
- Eric P. Palmer
- Anne Offermann
Institutions
- Colorado State University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0371
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22