A Blood-Based Assay for Detection of Patients with Advanced Adenomas
Blood-based screening for colorectal cancer could improve testing uptake and outcomes. We propose novel methods to detect AAs in plasma using cfDNA fragmentation patterns, cancer-associated proteins, and aneuploidy with high specificity. Larger studies are needed to validate clinical utility.
Authors
- Albert Kuo (ORCID: https://orcid.org/0000-0001-5155-0748)
- Cristian Tomasetti (ORCID: https://orcid.org/0000-0003-3277-4804)
- Lisa Dobbyn (ORCID: https://orcid.org/0000-0002-3159-189X)
- Natalie Silliman (ORCID: https://orcid.org/0000-0002-5198-9037)
- Anne Marie Lennon (ORCID: https://orcid.org/0000-0001-8957-3945)
- Joshua D. Cohen (ORCID: https://orcid.org/0000-0003-1158-5668)
- Christopher Douville (ORCID: https://orcid.org/0000-0002-2510-4151)
- Janine Ptak (ORCID: https://orcid.org/0000-0003-1934-8739)
- Nickolas Papadopoulos (ORCID: https://orcid.org/0000-0001-7135-7451)
- Kamel Lahouel (ORCID: https://orcid.org/0000-0002-4339-5749)
- Saad K. Ansari
- Maria Popoli (ORCID: https://orcid.org/0000-0003-2151-7749)
- Peter Gibbs (ORCID: https://orcid.org/0000-0003-1423-4484)
- Kenneth W. Kinzler (ORCID: https://orcid.org/0000-0001-5591-1176)
- Nadine Nehme (ORCID: https://orcid.org/0009-0001-3868-2305)
- Bert Vogelstein (ORCID: https://orcid.org/0000-0003-0766-3854)
- Robert E. Schoen (ORCID: https://orcid.org/0000-0001-7153-2766)
- Jeanne Tie (ORCID: https://orcid.org/0000-0001-9244-2057)
- Haley Grant (ORCID: https://orcid.org/0000-0002-8173-5302)
- Brenda Diergaarde (ORCID: https://orcid.org/0000-0002-3578-6547)
- Yuxuan Wang (ORCID: https://orcid.org/0000-0002-2932-6042)
Institutions
- Translational Genomics Research Institute (US)
- City Of Hope National Medical Center (US)
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Johns Hopkins Medicine (US)
- Peter MacCallum Cancer Centre (AU)
- Sidney Kimmel Cancer Center (US)
- City of Hope (US)
- University of Pittsburgh Medical Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0398
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- John Templeton Foundation
- Virginia and D.K. Ludwig Fund for Cancer Research
- Johns Hopkins University
- Swim Across America
- National Institutes of Health
- National Cancer Institute