Evaluation of LYR‐220 Mometasone Sinonasal Implants in Patients With Chronic Rhinosinusitis and Prior Ethmoid Surgery: Results From the Randomized, Blinded, Controlled BEACON Phase 2 Study
The BEACON study demonstrated safety, efficacy, feasibility, and tolerability of LYR-220 in patients with CRS who have had prior ESS. The primary endpoint was met, with no SAEs reported. LYR-220 demonstrated statistically significant, clinically relevant improvements in key symptomatic and objective efficacy endpoints.
Authors
- Misun Lee (ORCID: https://orcid.org/0009-0003-0555-3093)
- Robert M. Naclerio (ORCID: https://orcid.org/0000-0003-4016-9030)
- Stacey L. Silvers
- Amber Luong (ORCID: https://orcid.org/0000-0001-6078-8010)
- M. Scott Major
- Marina Mihova
- Lindsay Brayton
- Robert C. Kern (ORCID: https://orcid.org/0000-0002-8995-9175)
- Vineeta Belanger
- Richard Nieman
- Jeffrey S. Rosenbloom
- Brent A. Senior (ORCID: https://orcid.org/0000-0002-1503-3150)
- Randall A. Ow (ORCID: https://orcid.org/0000-0001-5151-5731)
- Zachary M. Soler (ORCID: https://orcid.org/0000-0002-4304-595X)
- Ela Sajjadi
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- Johns Hopkins Medicine (US)
- Lyndra Therapeutics (United States) (US)
- Carolina Ear, Nose and Throat Clinic (US)
- Alamo Colleges (US)
- Wasatch Molecular (United States) (US)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1002/alr.23567
- Citations
- 1
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.85