Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Chemoradiation affects the immune system of patients with cervical cancer with well-controlled HIV infection differently than those without HIV, yet their survival does not differ. This finding is an important step in understanding how management of HIV infection can modify cancer outcomes, particularly in settings with a high burden of HIV.
Authors
- Sheynaz Bassa (ORCID: https://orcid.org/0000-0001-5234-1577)
- Zhi Wei (ORCID: https://orcid.org/0000-0001-6059-4267)
- Doreen Ramogola‐Masire (ORCID: https://orcid.org/0000-0001-9624-8366)
- Surbhi Grover (ORCID: https://orcid.org/0000-0001-7443-5937)
- Dawn Balang
- Erle S. Robertson (ORCID: https://orcid.org/0000-0002-6088-2979)
- Memory Bvochora‐Nsingo
- Bokang Maswabi (ORCID: https://orcid.org/0000-0003-4699-5392)
- Xiang Lin (ORCID: https://orcid.org/0000-0002-7634-5780)
- Hao Shen (ORCID: https://orcid.org/0000-0002-5003-4992)
- Kebatshabile Ngoni (ORCID: https://orcid.org/0000-0002-2763-712X)
- Nicola M. Zetola (ORCID: https://orcid.org/0000-0003-0712-8579)
- Luis Cocka
- Sebathu Chiyapo (ORCID: https://orcid.org/0000-0001-9800-1455)
- Emily MacDuffie (ORCID: https://orcid.org/0000-0001-8479-8512)
Institutions
- New Jersey Institute of Technology (US)
- University of Botswana (BW)
- Hospital of the University of Pennsylvania (US)
- Pennsylvania Hospital (US)
- Augusta University Health (US)
- Gaborone University College Of Law and Professional Studies (BW)
- Botswana Harvard AIDS Institute Partnership (BW)
- Botswana-Baylor Children's Clinical Center of Excellence (BW)
- University of Pretoria (ZA)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0364
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- National Institutes of Health
- Center for AIDS Research, University of Washington
- National Cancer Institute