Genomic alterations in Bacteroides fragilis favor adaptation in colorectal cancer microenvironment
In summary, it is our assertion that the alterations observed in both core and nonessential genes of B. fragilis, which have been isolated from tissues of colorectal cancer patients, along with significant instances of horizontal gene transfer to the genome, are likely intended to enhance adaptation to the evolving conditions of the tumor microenvironment. This study may provide new insights into the interaction between B. fragilis and the CRC microenvironment.
Authors
- Dengmei Gong
- Xiaohu Xie (ORCID: https://orcid.org/0000-0002-0100-6370)
- Xia Yang (ORCID: https://orcid.org/0000-0001-5852-5916)
- Yu Gan (ORCID: https://orcid.org/0000-0003-3409-3412)
- Shenghai Jiang
- Maijian Wang
- Xianchang Zhu
- Yao Gong
- Jida Li (ORCID: https://orcid.org/0000-0002-2839-4393)
- Lei Qian (ORCID: https://orcid.org/0000-0002-2128-9048)
- Hao Yang (ORCID: https://orcid.org/0000-0002-6670-0769)
- Yu Zhang (ORCID: https://orcid.org/0009-0005-6052-7087)
Institutions
- Zunyi Medical University (CN)
- Guizhou Education University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12864-025-11421-3
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22