Transcriptional insights on the incomplete cytoplasmic maturation and developmental potential of oocytes cultured without granulosa cells in mice
We show that granulosa cells are important for both nuclear and cytoplasmic maturation of oocytes. Abnormal gene expression in oocytes with incomplete cytoplasmic maturation may be associated with potential defects in fertilization and embryonic development.
Authors
- Ziying Huang
- Yong Fan (ORCID: https://orcid.org/0000-0002-7107-773X)
- Tianjie Li (ORCID: https://orcid.org/0000-0003-4734-1577)
- Lin Fu (ORCID: https://orcid.org/0000-0003-1069-3560)
- Hanji Huang (ORCID: https://orcid.org/0000-0002-4128-2361)
- Heng Pan
- Yang Yu (ORCID: https://orcid.org/0000-0002-4310-1966)
- Yuxin Luo (ORCID: https://orcid.org/0000-0003-1956-6525)
- Yichuan Zhang (ORCID: https://orcid.org/0000-0003-3745-0083)
- Chenxi Xiao (ORCID: https://orcid.org/0000-0001-5885-1930)
- Yibo Wang (ORCID: https://orcid.org/0000-0001-9984-581X)
- Ping Zhou (ORCID: https://orcid.org/0000-0001-8125-3525)
- Wenfeng Xie
- Yong Qi (ORCID: https://orcid.org/0009-0002-8893-8441)
- Ren Yun
- Hongcui Zhao
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Guangxi Maternal and Child Health Hospital (CN)
- Peking University Third Hospital (CN)
- Beijing Friendship Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12864-025-11455-7
- Citations
- 4
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Beijing Nova Program