The influence of anti-aging approaches on testosterone levels in sedentary elderly men

Introduction. With thirty percent of the world's population not getting enough exercise, Worldwide, physical inactivity ranks as one of the most common cause of premature mortality. Rapid drops in physical activity, decreased mobility, and early morbidity are characteristics of aging. As the population over 80 continues to rise, aging raises the danger of age-related illnesses and changes in hormone release. Aim. Understanding the aging process is useful in developing pharmacological therapies and identifying therapeutic targets for age-related testosterone deficiency. Therefore, the purpose of this study is to present a thorough evaluation of the effects of anti-aging strategies on testosterone levels in older, inactive men. Methods. A literature search was completed for clinical and preclinical studies published in English between 2016 and 2024 related to age, sedentary life, testosterone, and anti-aging strategies. Results. Age-related diseases can be prevented and treated by anti-aging techniques including calorie restriction, a balanced diet, regular exercise, weight control, diabetes management, and quitting smoking. Regular exercise raises total testosterone, free testosterone, and muscle steroidogenesis. In older men, testosterone replacement treatment increases bone density, cholesterol, protein synthesis, strength, erectile function, sexual desire, and general cognitive performance. Dehydroepiandrosterone supplementation, however, may improve health without having a detrimental impact, perhaps reversing arterial age and lowering the risk of cardiovascular disorders, according to certain research. Conclusion. This article evaluates the prospects for anti-aging procedures to assist in reducing the adverse effects of aging and physical inactivity in men.