Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells
Our novel liposomal formulation encapsulating AP39 improves stability, promotes sustained release, and enhances BBB permeability while preserving antioxidant effects. These findings indicate that liposomal AP39 is a suitable therapeutic approach to further investigate in the treatment of neurodegenerative diseases.
Authors
- Manjit Kaur (ORCID: https://orcid.org/0000-0001-6259-2046)
- Mandeep Kaur Marwah (ORCID: https://orcid.org/0000-0003-4881-003X)
- Raj Badhan (ORCID: https://orcid.org/0000-0002-0904-9324)
- Hala Shokr (ORCID: https://orcid.org/0000-0002-0973-0558)
- Irundika H.K. Dias (ORCID: https://orcid.org/0000-0002-6620-8221)
- Lissette Sanchez-Aranguren (ORCID: https://orcid.org/0000-0002-4663-5752)
- Shakil Ahmad
- Lorena Diaz Sanchez (ORCID: https://orcid.org/0000-0002-4830-9256)
- Maninder Dhaliwal (ORCID: https://orcid.org/0000-0003-4221-718X)
- Mohamad Anas Al Tahan
Institutions
- Aston University (GB)
- University of Manchester (GB)
- Coventry University (GB)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s507697
- Citations
- 12
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 13.34
Funders
- UK Research and Innovation
- Biotechnology and Biological Sciences Research Council