Cardiometabolic protein expression levels and pathways associated with kidney function decline in older European adults with advanced kidney disease
Higher expression levels of proteins and biological pathways involving fibrogenesis and the complement cascade were found to be associated with kidney function loss. However, study limitations and unavailability of concurrent kidney cellular proteomic signatures necessitate further study.
Authors
- Kate Birnie (ORCID: https://orcid.org/0000-0002-9083-4097)
- P. Andreas Jonsson (ORCID: https://orcid.org/0000-0002-1938-0707)
- Brian Rayner (ORCID: https://orcid.org/0000-0002-0167-9591)
- Nicholas C Chesnaye (ORCID: https://orcid.org/0000-0003-4883-9174)
- Ryan Aylward (ORCID: https://orcid.org/0000-0002-3830-1795)
- Christoph Wanner (ORCID: https://orcid.org/0000-0001-9507-5301)
- Marie Evans (ORCID: https://orcid.org/0000-0001-8650-5795)
- Kitty J. Jager (ORCID: https://orcid.org/0000-0003-0444-8569)
- Yoav Ben‐Shlomo (ORCID: https://orcid.org/0000-0001-6648-3007)
- Christiane Drechsler (ORCID: https://orcid.org/0000-0002-0012-9707)
- Nicki Tiffin (ORCID: https://orcid.org/0000-0001-5083-2735)
- Roemer J. Janse (ORCID: https://orcid.org/0000-0003-0059-872X)
- Maciej Szymczak (ORCID: https://orcid.org/0000-0002-1248-081X)
- Samantha Hayward (ORCID: https://orcid.org/0000-0002-3234-7549)
- Friedo W. Dekker (ORCID: https://orcid.org/0000-0002-2433-2494)
- Fergus John Caskey (ORCID: https://orcid.org/0000-0002-5199-3925)
- Claudia Torino
- Vilasi Antonio Demetrio
Institutions
- South African Medical Research Council (ZA)
- North Bristol NHS Trust (GB)
- University of Cape Town (ZA)
- Leiden University Medical Center (NL)
- Southmead Hospital (GB)
- Karolinska Institutet (SE)
- University of Bristol (GB)
- Wroclaw Medical University (PL)
- Istituto di Fisiologia Clinica (IT)
- Universitätsklinikum Würzburg (DE)
- National Research Council (RO)
- Amsterdam University Medical Centers (NL)
- National Research Council (IT)
- University of Amsterdam (NL)
- Umeå University (SE)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1093/ckj/sfaf079
- Citations
- 2
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Institute for Health and Care Research
- University of Bristol
- Nierstichting
- Stockholms Läns Landsting
- Sveriges Läkarförbund
- Medical Research Council
- Center for Innovative Medicine