Inherited retinal degeneration in Malay and Indian populations of Singapore and Malaysia: a prospective multicentre study
This study demonstrated diverse phenotypic and genotypic outcomes in Malay and Indian populations of Singapore and Malaysia, with distinct differences between them. Homozygosity was common among ethnic Indian IRD cases, explaining phenotypic diversity. These findings inform the identification of regionally relevant IRDs for developing targeted therapies in Malay and Indian patients from Southeast Asia.
Authors
- Penny Pooi Wah Lott
- Yasmin M. Bylstra (ORCID: https://orcid.org/0000-0002-6420-2272)
- Saumya Shekhar Jamuar (ORCID: https://orcid.org/0000-0003-2341-8349)
- Beau James Fenner (ORCID: https://orcid.org/0000-0002-5356-7604)
- Tien‐En Tan (ORCID: https://orcid.org/0000-0002-9869-5159)
- Sylvia Kam (ORCID: https://orcid.org/0000-0001-7704-1917)
- Saadia Z. Farooqui
- Kanika Jain (ORCID: https://orcid.org/0000-0003-1826-4402)
- Weng Khong Lim (ORCID: https://orcid.org/0000-0003-4391-1130)
- Shaobing Su (ORCID: https://orcid.org/0000-0002-0404-4348)
- Ranjana S. Mathur
- Rachael W. C. Tang
- Choi Mun Chan
Institutions
- Agency for Science, Technology and Research (SG)
- SingHealth (SG)
- Nanyang Technological University (SG)
- Singapore National Eye Center (SG)
- University of Malaya (MY)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Ophthalmic Genetics
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1080/13816810.2025.2473961
- Citations
- 1
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- SingHealth Foundation