Targeting Active Microglia Alleviates Distal Edge of Proton Radiation-induced Neural Damage
This study demonstrated that proton radiation induces neuronal damage and accumulation of activated microglia at the distal edge. Targeting activated microglia may play a protective role in distal edge injury from radiation.
Authors
- Dan Ou (ORCID: https://orcid.org/0000-0001-9485-6042)
- Yingying Lin (ORCID: https://orcid.org/0009-0006-4404-8390)
- Li Zhou (ORCID: https://orcid.org/0000-0002-9965-7533)
- Fei Xu (ORCID: https://orcid.org/0000-0001-9922-1927)
- Ran Wu (ORCID: https://orcid.org/0000-0003-4048-5551)
- Lu Cao (ORCID: https://orcid.org/0000-0002-5159-7615)
- Yibin Zhang
- Jiayi Chen (ORCID: https://orcid.org/0000-0001-6417-290X)
- Jianyi Zhao
- Mei Chen
- Keman Liao
Institutions
- University of Shanghai for Science and Technology (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1016/j.adro.2025.101764
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00