The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment
This study showed that MCI patients with abnormal CSF pathological protein levels exhibit compensatory increases in FC of insular subregions, which in turn affect cognitive function. Our findings contributed to a better understanding of the pathophysiology and underlying neural mechanisms of MCI.
Authors
- Wenzhang Qi
- Yunlu Feng (ORCID: https://orcid.org/0000-0002-2761-100X)
- Chaoyong Xiao
- Yiming Ruan
- Chen Xue (ORCID: https://orcid.org/0000-0002-9753-0782)
- Zonghong Li
- Darui Zheng
- Qianqian Yuan (ORCID: https://orcid.org/0000-0002-0749-0749)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Brain Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-03-18
- DOI
- https://doi.org/10.3389/fnagi.2025.1506478
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94