Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis
Liver and a combination of myocardial and liver iron overload were associated with increased early diastolic filling and increased e/a ratio respectively, which may serve as markers of diastolic dysfunction. Impaired diastolic function, even in the absence of myocardial iron overload was associated with liver iron metabolism and may indicate early cardiac involvement, while left ventricular systolic function is still preserved.
Authors
- Benedikt Bernhard (ORCID: https://orcid.org/0000-0002-0996-9681)
- Daniel Ott (ORCID: https://orcid.org/0000-0002-8108-8707)
- Jonathan Schütze (ORCID: https://orcid.org/0000-0002-3405-5443)
- Kim N. Cajachagua‐Torres (ORCID: https://orcid.org/0000-0002-0213-6935)
- Hendrik von Tengg‐Kobligk (ORCID: https://orcid.org/0000-0003-3207-3223)
- Alan A. Peters (ORCID: https://orcid.org/0000-0002-9864-6381)
- Adam Bakula (ORCID: https://orcid.org/0000-0002-5657-0032)
- Christoph Gräni (ORCID: https://orcid.org/0000-0001-6029-0597)
- Taulant Muka (ORCID: https://orcid.org/0000-0003-3235-3073)
- Anselm W. Stark (ORCID: https://orcid.org/0000-0002-5861-3753)
- Andreas Wahl
- Jan C. Zurkirchen
- Hugo G. Quezada‐Pinedo (ORCID: https://orcid.org/0000-0002-0641-7718)
- Noushin Sadat Ahanchi (ORCID: https://orcid.org/0000-0003-2824-3648)
- Catherine Gebhard
Institutions
- University of Bern (CH)
- Duke University (US)
- University Hospital of Bern (CH)
- Institute of Social and Preventive Medicine (CH)
- New York University (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.3389/fcvm.2025.1547161
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63