Single-cell RNA sequencing and spatial transcriptomics reveal the heterogeneity and intercellular communication of cancer-associated fibroblasts in gastric cancer
Our study provided a comprehensive characterization of CAF heterogeneity in gastric cancer and revealed the intricate intercellular networks within the TME. The identified CAF subpopulations and their interactions with malignant cells could serve as potential therapeutic targets.
Authors
- Yuzhou Zhao
- Sen Li (ORCID: https://orcid.org/0009-0000-7846-3134)
- Bo Ren (ORCID: https://orcid.org/0000-0002-8242-0337)
- Xijie Zhang (ORCID: https://orcid.org/0000-0001-7353-9283)
- Wence Zhou (ORCID: https://orcid.org/0000-0002-0529-7777)
- Rui Wang (ORCID: https://orcid.org/0000-0003-3830-4133)
- Бо Лю (ORCID: https://orcid.org/0000-0003-3045-628X)
Institutions
- Zhengzhou University (CN)
- Lanzhou University Second Hospital (CN)
- Henan Cancer Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12967-025-06376-8
- Citations
- 29
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 23.37
Funders
- National Natural Science Foundation of China