Background Tissue with Native Target Expression Can Determine Presence of Nodal Metastasis in Head and Neck Squamous Cell Carcinoma Patients Infused with Targeted Fluorescent Tracers
In HNSCC patients infused with a molecularly targeted fluorescent tracer, endogenous expression of the target antigen can be used as a reference standard to detect LN metastasis. Additionally, the performance of the background in determining metastatic LN can be improved by utilizing patient-specific reference standards.
Authors
- Marisa E. Hom (ORCID: https://orcid.org/0000-0003-1319-5110)
- Hidenori Tanaka (ORCID: https://orcid.org/0000-0002-7516-9180)
- Giri Krishnan (ORCID: https://orcid.org/0000-0002-4196-9155)
- Benjamin B. Kasten (ORCID: https://orcid.org/0000-0001-9918-0379)
- Nicole Meeks (ORCID: https://orcid.org/0009-0007-4021-8636)
- Sherin James (ORCID: https://orcid.org/0000-0002-1036-5842)
- Jason M. Warram (ORCID: https://orcid.org/0000-0001-5230-0011)
- Eben Lloyd Rosenthal (ORCID: https://orcid.org/0000-0003-0294-5203)
- Y.-J. Lee (ORCID: https://orcid.org/0000-0001-7050-9185)
- Akhilesh Wodeyar
Institutions
- University of Alabama at Birmingham (US)
- The University of Adelaide (AU)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1007/s11307-025-01996-4
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- Vanderbilt Institute for Clinical and Translational Research