Sample size recalculation based on the overall success rate in a randomized test-treatment trial with restricting randomization to discordant pairs
It may be advisable to consider blinded recalculation of sample size in a randomized test-treatment study with restriction of randomization to discordant pairs in order to improve the conduct of the study. However, there are a number of study-related limitations that affect the implementation of the method which need to be considered.
Authors
- Oke Gerke (ORCID: https://orcid.org/0000-0001-6335-3303)
- Caroline Elzner
- Amra Pepić (ORCID: https://orcid.org/0000-0002-9266-4554)
- Antonia Zapf (ORCID: https://orcid.org/0000-0002-8467-0508)
Institutions
- Statistisches Bundesamt (DE)
- Universität Hamburg (DE)
- University of Southern Denmark (DK)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12874-024-02410-3
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00