Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score
In this gene-environment interaction study, a combination of long-term air pollution exposure and genetic susceptibility strongly contributed to the risk of developing PD. Widespread exposure to air pollution makes TRAP an important modifiable risk factor affecting large populations globally, particularly individuals with genetic vulnerability.
Authors
- Christina M. Lill (ORCID: https://orcid.org/0000-0002-2805-1307)
- Jun Wu (ORCID: https://orcid.org/0000-0002-2693-7112)
- Cynthia Kusters (ORCID: https://orcid.org/0000-0001-8099-9026)
- Matthias Ketzel (ORCID: https://orcid.org/0000-0001-9519-1935)
- Jeff M. Bronstein (ORCID: https://orcid.org/0000-0002-2961-8918)
- Johnni Hansen (ORCID: https://orcid.org/0000-0002-9342-2725)
- Dayoon Kwon (ORCID: https://orcid.org/0000-0001-7967-8508)
- Kimberly C. Paul (ORCID: https://orcid.org/0000-0002-4476-2352)
- Beate Ritz (ORCID: https://orcid.org/0000-0001-6976-7339)
- Ole Raachou-Nielsen
Institutions
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- Aarhus University (DK)
- University of Münster (DE)
- University of Surrey (GB)
- Neurobehavioral Systems (US)
- Irvine University (US)
- Danish Cancer Society (DK)
- Imperial College London (GB)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.0854
- Citations
- 7
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 8.40