MicroRNA-24-3p targeting Top1 in perirenal fat is involved in circulating inflammation and high cardiovascular disease risk in patients with primary aldosteronism
The upregulation of miR-24-3p in the perirenal fat induced inflammation and oxidative stress by targeting Top1, which may contribute to a high risk of CVD in patients with PA.
Authors
- Renyi Zhang (ORCID: https://orcid.org/0000-0003-4622-6817)
- Meiping Guan (ORCID: https://orcid.org/0000-0002-9709-9320)
- Feifei Cai
- Chuyi Yang (ORCID: https://orcid.org/0000-0002-4901-8266)
- Qijian Feng
- Yanmei Zeng (ORCID: https://orcid.org/0000-0002-9366-6252)
- Yuan Wang (ORCID: https://orcid.org/0000-0001-9189-3630)
- Jin Zhang (ORCID: https://orcid.org/0000-0001-7145-7823)
- Wei Zhao (ORCID: https://orcid.org/0000-0001-8440-2274)
- Yuejun Du
- Lei Guo (ORCID: https://orcid.org/0000-0002-0107-0671)
- Lingling Xu (ORCID: https://orcid.org/0000-0003-2731-4758)
- Nannan Liu (ORCID: https://orcid.org/0000-0002-3088-9387)
- Min Luo (ORCID: https://orcid.org/0000-0002-5300-3462)
- Xuelin Li (ORCID: https://orcid.org/0000-0001-7393-6211)
- Huiyun Wang
- Peili Wu
- Xiaochun Lin
- Yuxuan Hu (ORCID: https://orcid.org/0009-0004-3558-4584)
- Minghai Wu
Institutions
- Nanfang Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12967-025-06329-1
- Citations
- 4
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province