Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling
Our findings suggest that sodium citrate supplementation during CAR-T cell expansion could be a promising strategy to improve CAR-T therapy for solid tumors by preventing exhaustion and promoting memory T cell formation.
Authors
- Muya Zhou (ORCID: https://orcid.org/0000-0002-2219-071X)
- Xudong Ao
- Junqing Liang (ORCID: https://orcid.org/0000-0002-1525-4367)
- Wenying Li (ORCID: https://orcid.org/0000-0002-7104-3505)
- Xuechen Yin (ORCID: https://orcid.org/0000-0002-6478-0101)
- Zhigang Guo
- Luxia Xu (ORCID: https://orcid.org/0009-0003-5846-5724)
- Jiaqi Liu (ORCID: https://orcid.org/0000-0001-5595-5988)
- Wenwen Chen (ORCID: https://orcid.org/0000-0002-5958-2696)
- Xinping Wang (ORCID: https://orcid.org/0000-0001-7067-2986)
- Jianhua Hu (ORCID: https://orcid.org/0000-0002-1749-3636)
- Lingfeng He (ORCID: https://orcid.org/0000-0002-9668-419X)
- Jun Cao
- Tinghui Huang
Institutions
- Nanjing Normal University (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1540754
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14