Nanoparticle platform preferentially targeting liver sinusoidal endothelial cells induces tolerance in CD4+ T cell-mediated disease models
Our findings demonstrate that peptide-loaded nanoparticles preferentially deliver disease-relevant peptides to LSECs, thereby inducing antigen-specific immune tolerance. This versatile clinical-stage nanoparticle platform holds promise for clinical application across multiple autoimmune diseases.
Authors
- Reinaldo Digigow (ORCID: https://orcid.org/0000-0002-4525-7817)
- Disha Mungalpara
- Sabine Fleischer (ORCID: https://orcid.org/0000-0002-8102-8659)
- Isabelle Serr (ORCID: https://orcid.org/0000-0001-9277-9055)
- Cornelia Gottwick (ORCID: https://orcid.org/0000-0003-3373-162X)
- Dikran Sarko
- Agata Widera
- A. Vocaturo
- Muhammad Alsamman
- Daria Krzikalla (ORCID: https://orcid.org/0009-0000-1921-8905)
- Marco Fanzutti
- Christian Schröter (ORCID: https://orcid.org/0000-0002-8161-7568)
- Johannes Herkel (ORCID: https://orcid.org/0000-0001-9055-9999)
- Carolin Daniel (ORCID: https://orcid.org/0000-0003-4698-7069)
- Muharrem Şeleci
- Antonella Carambia (ORCID: https://orcid.org/0000-0002-6484-3424)
- Markus Heine (ORCID: https://orcid.org/0000-0001-9761-8250)
- Alexey Surnov
- Lázaro José Batista Da Silva Mesquita (ORCID: https://orcid.org/0009-0003-5851-9964)
- Johannes Pohlner (ORCID: https://orcid.org/0000-0003-4465-2142)
- Shu-Hung Wang (ORCID: https://orcid.org/0000-0003-4071-4748)
- Cristina de Min
- Barbara Metzler
- Miriam Zahlten
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Isarna Therapeutics (Germany) (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1542380
- Citations
- 3
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung