Unveiling the Role of Protein Posttranslational Modifications in Glioma Prognosis
Our study establishes the first comprehensive PTM atlas in gliomas, revealing subtype-specific modification patterns with clinical and therapeutic implications. TOM1L1 emerges as a promising prognostic biomarker and a potential therapeutic intervention target. Targeting PTM pathways may offer novel strategies for glioma treatment, enhancing patient outcomes.
Authors
- Xingjun Jiang (ORCID: https://orcid.org/0000-0002-9689-2669)
- Hanxue Huang
- Youwei Guo (ORCID: https://orcid.org/0000-0002-0989-1327)
- Zihan Wang (ORCID: https://orcid.org/0000-0001-8193-7054)
- Lei Wang (ORCID: https://orcid.org/0000-0002-0664-2704)
- Caiping Ren (ORCID: https://orcid.org/0000-0001-6880-7394)
- Weidong Liu (ORCID: https://orcid.org/0000-0002-5449-9180)
- Hailong Huang (ORCID: https://orcid.org/0000-0002-6201-8244)
- Zhipeng Jiang (ORCID: https://orcid.org/0009-0008-4861-1739)
- Wen Yin (ORCID: https://orcid.org/0000-0002-4734-9483)
- Haoxuan Huang
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70330
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Natural Science Foundation of Hunan Province