Digital PCR Assay Utilizing In‐Droplet Methylation‐Sensitive Digestion for Estimation of Fetal cfDNA From Plasma
This study showcases the potential of this novel, 6-color, high-multiplex methylation ddPCR panel for accurate measurement of fetal fraction in cfDNA samples. It presents opportunities to integrate such methodology as a standalone measurement to assess the quality of samples undergoing NIPS.
Authors
- Raymond‐John Abayan
- Olga Mikhaylichenko
- Séverine Margeridon
- Xinhua Lin (ORCID: https://orcid.org/0000-0002-9380-8417)
- Nazeeh Hanna (ORCID: https://orcid.org/0000-0003-2167-5712)
- Nathan L. Hendel
- Maria F. Gencoglu
- Martin Chavez (ORCID: https://orcid.org/0000-0003-2452-715X)
- David S. Siegel (ORCID: https://orcid.org/0000-0002-3604-2574)
- Eric Hall (ORCID: https://orcid.org/0000-0003-0244-7458)
- Madhumita Ramesh
- Richard Dannebaum
- Thea Riel
- Anthony Henriquez
- Kristin Loomis (ORCID: https://orcid.org/0000-0002-5812-3447)
- Chenyu Li (ORCID: https://orcid.org/0000-0001-8028-6691)
- Mónica Herrera
- Nyari Dzvova
Institutions
- Bio-Rad (United States) (US)
- Long Island University (US)
- New York University (US)
Publication Details
- Journal
- Prenatal Diagnosis
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1002/pd.6774
- Citations
- 4
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development