The anti-inflammatory effects of vitamin B6 on neuroinflammation and neuronal damage caused by 1,2-diacetylbenzene in BV2 microglial and sH-SY5Y cells
Our findings indicate that vitamin B6 may protect against DAB-induced cognitive impairment by attenuating key inflammatory pathways, reducing oxidative stress, and inhibiting tau hyperphosphorylation, β-amyloid production, and GSK-3β Tyr216 phosphorylation. This highlights its potential as a therapeutic agent for cognitive impairment.
Authors
- Won Hee Jo
- Hai Duc Nguyen (ORCID: https://orcid.org/0000-0001-8419-7784)
- Ngoc Hoang (ORCID: https://orcid.org/0000-0003-0624-9686)
- Min‐Sun Kim (ORCID: https://orcid.org/0000-0001-9952-0038)
Institutions
- Sunchon National University (KR)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1080/08923973.2025.2469216
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53