Impacts of metabolic syndrome diseases on long-term outcomes of chronic hepatitis B patients treated with nucleos(t)ide analogues
Having two or more metabolic diseases was associated with a higher risk of cirrhosis, overall death, and non-liver-related death, but having diabetes as a single metabolic disease was significantly associated with all adverse outcomes including cirrhosis, HCC, and overall, liver-related, and non-liver-related death.
Authors
- Pei‐Chien Tsai (ORCID: https://orcid.org/0000-0002-5044-6727)
- Norio Itokawa (ORCID: https://orcid.org/0009-0002-2390-6692)
- Daniel Q. Huang (ORCID: https://orcid.org/0000-0002-5165-5061)
- Wan‐Long Chuang (ORCID: https://orcid.org/0000-0002-2376-421X)
- Yasuhito Tanaka (ORCID: https://orcid.org/0000-0002-2473-6966)
- Satoshi Yasuda (ORCID: https://orcid.org/0000-0002-7470-5236)
- Keigo Kawashima (ORCID: https://orcid.org/0000-0003-0985-1111)
- Cheng‐Hao Tseng (ORCID: https://orcid.org/0000-0003-4507-2414)
- Sebastián Marciano (ORCID: https://orcid.org/0000-0002-7983-1450)
- Ramsey Cheung (ORCID: https://orcid.org/0000-0002-0211-7013)
- Hidenori Toyoda (ORCID: https://orcid.org/0000-0002-1652-6168)
- Adrian Carlos Gadano (ORCID: https://orcid.org/0000-0002-3590-2472)
- Makoto Chuma (ORCID: https://orcid.org/0000-0002-0963-9172)
- Jang Han Jung (ORCID: https://orcid.org/0000-0001-7875-2868)
- Yao‐Chun Hsu (ORCID: https://orcid.org/0000-0001-8984-5103)
- Tomonori Senoh
- Mindie H. Nguyen (ORCID: https://orcid.org/0000-0002-6275-4989)
- Dae Won Jun (ORCID: https://orcid.org/0000-0002-2875-6139)
- Eileen Laureal Yoon (ORCID: https://orcid.org/0000-0003-0474-048X)
- Akito Nozaki (ORCID: https://orcid.org/0000-0003-2269-101X)
- Jee‐Fu Huang (ORCID: https://orcid.org/0000-0002-2752-7051)
- Ritsuzo Kozuka (ORCID: https://orcid.org/0000-0002-0763-6760)
- Hyunwoo Oh (ORCID: https://orcid.org/0000-0003-4224-8808)
- Philip Vutien (ORCID: https://orcid.org/0000-0002-4196-6077)
- Chung‐Feng Huang (ORCID: https://orcid.org/0000-0002-3367-068X)
- Sang Bong Ahn (ORCID: https://orcid.org/0000-0001-7419-5259)
- Masatoshi Ishigami (ORCID: https://orcid.org/0000-0003-0938-631X)
- Soung Won Jeong (ORCID: https://orcid.org/0000-0003-2855-6011)
- Kazuhiro Takahashi (ORCID: https://orcid.org/0000-0003-1900-4389)
- Ming‐Lung Yu (ORCID: https://orcid.org/0000-0001-8145-1900)
- Toru Ishikawa (ORCID: https://orcid.org/0000-0002-5470-9694)
- T. Honda (ORCID: https://orcid.org/0000-0003-4121-8957)
- Angela Chau (ORCID: https://orcid.org/0000-0001-9863-6370)
- Tsunamasa Watanabe (ORCID: https://orcid.org/0000-0002-7659-914X)
- Koichi Takaguchi (ORCID: https://orcid.org/0000-0003-0175-8721)
- Masaru Enomoto (ORCID: https://orcid.org/0000-0002-4028-4381)
- Sung Eun Kim (ORCID: https://orcid.org/0000-0001-6236-780X)
- Jie Li (ORCID: https://orcid.org/0000-0002-4433-5393)
- Hiroshi Abe (ORCID: https://orcid.org/0000-0002-8298-1329)
- Haruki Uojima
- Joanne Kimiko Liu (ORCID: https://orcid.org/0000-0002-3457-8519)
- Chia-Yen Dai
- Masanori Atsukawa
- Chao Wu
- Rui Huang (ORCID: https://orcid.org/0000-0002-4103-8537)
- Huy N. Trinh
- Gi-Ae Kim
- Kaori Inoue (ORCID: https://orcid.org/0009-0007-8770-2011)
- Mayumi Maeda (ORCID: https://orcid.org/0000-0001-6946-5082)
- Kunihiko Tsuji
- Ming-Lun Yeh
- Takanori Ito (ORCID: https://orcid.org/0000-0002-1879-3550)
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- St. Marianna University School of Medicine (JP)
- National University of Singapore (SG)
- Saga University (JP)
- University of Washington (US)
- VA Palo Alto Health Care System (US)
- Eulji University (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Yokohama City University Medical Center (JP)
- Hospital Italiano de Buenos Aires (AR)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Nagoya City University (JP)
- Kyung Hee University (KR)
- Social Insurance Yokohama Central Hospital (JP)
- E-Da Hospital (TW)
- National Center for Global Health and Medicine (JP)
- Kangbuk Samsung Hospital (KR)
- Saiseikai Niigata Daini Hospital (JP)
- Nanjing Drum Tower Hospital (CN)
- Ogaki Municipal Hospital (JP)
- Hodogaya Chemical (Japan) (JP)
- Shinmatsudo Central General Hospital (JP)
- Stanford Medicine (US)
- Teine Keijinkai Hospital (JP)
- National University Hospital (SG)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Kagawa Prefectural Central Hospital (JP)
- Hallym University Sacred Heart Hospital (KR)
- Universidad Hospital Italiano (AR)
- Osaka Metropolitan University (JP)
- Hanyang University (KR)
- Nagoya University (JP)
- Kitasato University (JP)
- Tokyo Metropolitan University (JP)
- Nippon Medical School (JP)
- Sungkyunkwan University (KR)
- Nanjing University (CN)
- Yokohama City University (JP)
- Kumamoto University (JP)
- Stanford University (US)
- I-Shou University (TW)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3350/cmh.2024.1070
- Citations
- 11
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 14.90