LRRC8A in endothelial cells contributes to the aberrant blood-brain barrier integrity in ischaemic stroke
LRRC8A in BMVECs plays a pivotal role in modulating BBB integrity, a process regulated by WNK1. As an LRRC8A inhibitor, Eupatorin holds the potential for ischaemic stroke therapy.
Authors
- Huiran Zhang (ORCID: https://orcid.org/0000-0001-8105-2715)
- Huaxing Zhang (ORCID: https://orcid.org/0000-0002-7060-0808)
- Hailin Zhang (ORCID: https://orcid.org/0000-0002-0827-1425)
- Zhongmin Wu (ORCID: https://orcid.org/0000-0002-1707-0238)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0001-6677-2204)
- Chang Liu (ORCID: https://orcid.org/0000-0002-2957-0897)
- Wei Wang (ORCID: https://orcid.org/0009-0003-7539-9394)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0687-7113)
- Yue Kong
- Yanfei Tian
- Xiaona Du (ORCID: https://orcid.org/0000-0003-3939-672X)
- Yupeng Zhao (ORCID: https://orcid.org/0009-0006-2445-8069)
- Yan Wang (ORCID: https://orcid.org/0000-0001-6111-5379)
Institutions
- Hebei Medical University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Shijiazhuang University (CN)
- Center for Vascular Biology Research (US)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Stroke and Vascular Neurology
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1136/svn-2024-003675
- Citations
- 2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China