Ruminococcus bromii-generated acetate alleviated Clonorchis sinensis-induced liver fibrosis in mice
<i>R. bromii</i> exerted a protective effect on hepatic fibrosis by delivering acetate via the gut-liver axis to active the PI3K/AKT signaling pathway in HSCs. Furthermore, <i>R. bromii</i> can be used as a probiotic therapy to alleviate hepatic fibrosis.
Authors
- Xiaohong Peng (ORCID: https://orcid.org/0000-0001-9043-5603)
- Changsheng Cheng
- Chun Li (ORCID: https://orcid.org/0000-0002-8819-2443)
- Deping Cao (ORCID: https://orcid.org/0000-0002-1973-8879)
- Xin Zhong (ORCID: https://orcid.org/0000-0002-8903-819X)
- Liping Jiang (ORCID: https://orcid.org/0000-0001-8050-4193)
- Guoyang Huang
- Gang Mo
Institutions
- Guangxi University (CN)
- Guilin Medical University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3389/fmicb.2025.1532599
- Citations
- 6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.13