Metformin upregulates circadian gene PER2 to inhibit growth and enhance the sensitivity of glioblastoma cell lines to radiotherapy via SIRT2/G6PD pathway
We found the pivotal role of metformin as an effective circadian rhythm regulator. Targeting circadian clock gene to modify and rescue the dysfunctional circadian clock of GBM cells at molecular level might be an innovative way to administer cancer chronotherapy and maintain metabolic homeostasis in real world practice.
Authors
- Yifan Zhang (ORCID: https://orcid.org/0000-0001-6488-6232)
- J. F. Sun
- Zheng Feei (ORCID: https://orcid.org/0000-0002-7276-2229)
- Yang Wanfu
- Haifeng Jiang (ORCID: https://orcid.org/0000-0002-0995-3225)
- Faxuan Wang (ORCID: https://orcid.org/0000-0001-5297-4040)
- Hai-Liang Li (ORCID: https://orcid.org/0000-0002-4497-5649)
- Li Hou (ORCID: https://orcid.org/0000-0003-2524-2885)
- Hechun Xia (ORCID: https://orcid.org/0000-0002-3058-8162)
Institutions
- Ningxia Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3389/fphar.2025.1563865
- Citations
- 3
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 2.74