Identification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation
Six genes, including TNF, CXCL8, IL-6, IL-1β, IL-2, and IL-10, were associated with three major signaling pathways: the COVID-19 adverse outcome pathway, an overview of pro-inflammatory and pro-fibrotic mediators, and the interleukin-10 signaling pathway. Additionally, 12 targeted drugs were identified as potential therapeutic agents.
Authors
- Yunfeng Lin (ORCID: https://orcid.org/0000-0003-1224-6561)
- Guobin Song
- Dong‐Hua Yang (ORCID: https://orcid.org/0000-0001-8649-5531)
- Xiangdong Chen (ORCID: https://orcid.org/0000-0002-1533-8130)
- Tianhao Zhang (ORCID: https://orcid.org/0000-0002-4339-210X)
- Yuanyuan Ding (ORCID: https://orcid.org/0000-0001-7588-2181)
- Shujun Sun
- Rui Chen (ORCID: https://orcid.org/0000-0002-0696-3313)
- Jiwei Shen (ORCID: https://orcid.org/0009-0004-6235-5365)
Institutions
- Union Hospital (HK)
- Zhejiang Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3389/fmed.2025.1502189
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Natural Science Foundation of Hubei Province