Utility of <scp>SOX17</scp> Immunohistochemical Stain in Serous Fluid Cytology Cell Block Specimens

In this study, all tumors of gynecologic tract origin in effusion SFCS were SOX17 positive, while all other non-gynecologic tumors were negative for SOX17 except for one case. This finding suggests that SOX17 IHC is an excellent addition to the IHC panel while working up tumors at metastatic sites, specifically when gynecologic primary tumors are in the differential diagnosis.

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Publication Details

Journal
Diagnostic Cytopathology
Published
2025-03-17
DOI
https://doi.org/10.1002/dc.25468
Primary Topic
Renal and related cancers
Type
article
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article

Utility of SOX17 Immunohistochemical Stain in Serous Fluid Cytology Cell Block Specimens

Syed M. Gilani, Xulang Zhang, Neharika Shrestha
Diagnostic Cytopathology
Renal and related cancers
article

Utility of SOX17 Immunohistochemical Stain in Serous Fluid Cytology Cell Block Specimens

Syed M. Gilani, Xulang Zhang, Neharika Shrestha
article en

Abstract

In this study, all tumors of gynecologic tract origin in effusion SFCS were SOX17 positive, while all other non-gynecologic tumors were negative for SOX17 except for one case. This finding suggests that SOX17 IHC is an excellent addition to the IHC panel while working up tumors at metastatic sites, specifically when gynecologic primary tumors are in the differential diagnosis.

Diagnostic CytopathologyVol. 53(6)
Albany Medical Center Hospital (US)
Good health and well-being
Openalex Percentile: Top 95%
Renal and related cancers
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