Big data determination and validation of reference range for 24 hour urine cortisol by LCMS/MS
We used mass population data, where the prevalence of CS was likely very rare, plus a carefully phenotyped sample where CS was considered but excluded, to derive a validated reference interval for 24-h UFC by mass spectrometry in populations that reflect real-world use of the test. Given the highly skewed upper tail of the population distribution, it is probable that high test specificity for CS will require multimodality diagnostic confirmation.
Authors
- Danny Orton (ORCID: https://orcid.org/0000-0002-0253-6859)
- Erik Venos (ORCID: https://orcid.org/0000-0001-6071-5962)
- Doris M. Campbell
- Gregory Kline (ORCID: https://orcid.org/0000-0002-8129-9360)
- Alexander A. C. Leung (ORCID: https://orcid.org/0000-0002-7536-8497)
Institutions
- University of British Columbia (CA)
- University of Calgary (CA)
- Osaka Women's and Children's Hospital (JP)
- Women's Hospital (US)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1093/ejendo/lvaf054
- Citations
- 1
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29