Neutrophil Elastase Limits Spread of <i>Staphylococcus aureus</i> during Skin Infection
Neutrophil elastase (NE), the main protease of neutrophils, is involved in many of their functions, including prevention of infections. Despite its general importance, NE was previously thought to play no role in infections caused by Staphylococcus aureus, one of the leading bacterial pathogens. Here, using transgenic mice deficient in NE and a mouse model of localized skin infection, we demonstrate that NE is in fact needed for the containment of S. aureus and prevention of the systemic spread of this bacterium. This is apparently due to the role of NE in the formation of neutrophil extracellular traps.
Authors
- Justyna Folkert (ORCID: https://orcid.org/0000-0003-3789-5429)
- Amir Aliramezani (ORCID: https://orcid.org/0000-0002-0252-0945)
- Joanna Kozieł (ORCID: https://orcid.org/0000-0003-3436-6425)
- Jan Potempa (ORCID: https://orcid.org/0000-0002-3600-7461)
- Jakub M. Kwiecinski (ORCID: https://orcid.org/0000-0001-9472-2896)
- Izabela Ciastoń (ORCID: https://orcid.org/0000-0001-7545-0135)
- Michał Kanoza
Institutions
- Jagiellonian University (PL)
- University of Louisville (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1093/infdis/jiaf128
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Fundacja na rzecz Nauki Polskiej
- Uniwersytet Jagielloński w Krakowie
- Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie