Base-mediated synthesis of ring-fluorinated imidazo[1,2-<i>a</i>]pyridines <i>via</i> sequential C–F substitutions
Developing innovative approaches for the synthesis of compounds that integrate imidazo[1,2-<i>a</i>]pyridines and fluoro fragments is crucial. Herein, an expedient [3 + 3] annulation method for synthesizing ring-fluorinated imidazo[1,2-<i>a</i>]pyridines <i>via</i> two consecutive C-F substitutions from readily available 1<i>C</i>,3<i>N</i>-dinucleophiles and β-CF<sub>3</sub>-1,3-enynes is presented. This protocol exhibits several appealing features, including readily available and inexpensive substrates, a broad range of functional groups, step and atom economy, and mild reaction conditions without any transition-metal catalysts.
Authors
- Wen‐Juan Hao (ORCID: https://orcid.org/0000-0002-0646-7192)
- Feng Xue (ORCID: https://orcid.org/0000-0003-3732-6912)
- Kelu Yan (ORCID: https://orcid.org/0000-0002-1551-267X)
- Qiuyun Li
- Zhongfei Han
- Fan Zhang (ORCID: https://orcid.org/0000-0003-2319-6133)
- Bo Jiang (ORCID: https://orcid.org/0000-0003-3878-515X)
- Wei David Wang (ORCID: https://orcid.org/0000-0003-2864-5102)
- Tianyu Du
- Yannan Zhu (ORCID: https://orcid.org/0000-0002-4458-2490)
Institutions
- Jiangsu Normal University (CN)
- Qufu Normal University (CN)
- Yancheng Institute of Technology (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00035a
- Citations
- 1
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.94