Impact of phenytoin and valproic acid on cytotoxicity and inflammatory mediators in human mononuclear cells: with and without lipopolysaccharide stimulation
Phenytoin and VPA induced significant cytotoxic and inflammatory responses, influenced by dosage and LPS exposure. Val-75 exhibited a dose-specific immunomodulatory effect, reducing both pro-inflammatory and immune markers.
Authors
- Omar Omar (ORCID: https://orcid.org/0000-0002-2610-1294)
- Norah Alotaibi (ORCID: https://orcid.org/0000-0001-6450-8776)
- Nada Alzahrani
- Faisal E. Aljofi (ORCID: https://orcid.org/0000-0002-1652-5325)
- Marwa Madi (ORCID: https://orcid.org/0000-0002-3014-0405)
- Aminah Alesawy (ORCID: https://orcid.org/0000-0001-9969-8274)
- Nada Aldossary
- Marwa Alalshaikh
Institutions
- King Fahd Hospital of the University (SA)
- Imam Abdulrahman Bin Faisal University (SA)
Publication Details
- Journal
- PeerJ
- Published
- 2025-03-17
- DOI
- https://doi.org/10.7717/peerj.19102
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00