Exploring the Association Between Immune Cell Phenotypes and Osteoporosis Mediated by Inflammatory Cytokines: Insights from GWAS and Single-Cell Transcriptomics
Inflammatory cytokines play a crucial role in the pathogenesis of immunity-related osteoporosis. In particular, IgD+ CD24+ B cell %lymphocyte increase the risk of osteoporosis by modulating the levels of interleukin-17C. Our results provide evidence to support the link between immunity and osteoporosis and offer new therapeutic strategies for targeting inflammatory pathways in immune-mediated osteoporosis.
Authors
- Fengge Zhou (ORCID: https://orcid.org/0000-0001-7159-6647)
- Shouxiang Kuang
- Lei Sun (ORCID: https://orcid.org/0000-0001-8772-3217)
- Chenggui Zhang
- Chang Wang (ORCID: https://orcid.org/0009-0002-4683-7212)
- Li Yang (ORCID: https://orcid.org/0000-0002-7880-2113)
- Guodong Wang (ORCID: https://orcid.org/0000-0001-8088-849X)
- Jianmin Sun (ORCID: https://orcid.org/0000-0002-7989-7660)
- Xiaoqing Ma
Institutions
- Affiliated Hospital of Taishan Medical University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/itt.s510102
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39