A case of male vulvar acantholytic squamous cell Carcinoma

ASCC lacks specific clinical and imaging features, its clinical presentation is similar to that of other skin cancers such as basal cell carcinoma and preoperative diagnosis is difficult. The diagnosis depends on postoperative histopathological examination, often supplemented by immunohistochemistry. Surgical resection is the main treatment, but the prognosis is controversial. It accounts for about 4. 9% of all squamous cell carcinoma cases. It is more common in the elderly, and males have a significantly higher incidence rate than females. It mainly occurs in the head and neck and other exposed sites. ASCC in the vulva is rare, but it is highly aggressive, with a high risk of metastasis and poor prognosis. This article reports a case of vulva. A 54-year-old man with ASCC was reported. By analyzing the clinical features, pathogenesis, etiology, differential diagnosis, treatment and prognosis of ASCC, we aimed to provide reference for clinical management.