Metatranscriptomic profiling reveals pathogen and host response signatures of pediatric acute sinusitis and upper respiratory infection
Our study provides a one-of-kind dataset that profiles the interplay between pathogen infection and host responses in pediatric AS and URI. It reveals bacterial and viral-specific host responses that could enable new diagnostic approaches and demonstrates the potential of untargeted RNA-seq in diagnostic analysis of AS and URI.
Authors
- Briallen Lobb (ORCID: https://orcid.org/0000-0001-7921-0972)
- Manjot S. Hunjan
- Andrew C. Doxey (ORCID: https://orcid.org/0000-0003-2015-099X)
- Jeremy A. Hirota (ORCID: https://orcid.org/0000-0003-2429-4165)
- Marcia Kurs‐Lasky
- John V. Williams (ORCID: https://orcid.org/0000-0001-8377-5175)
- Nooran Abu Mazen
- Vivian H. Chu (ORCID: https://orcid.org/0000-0002-2397-4970)
- William MacDonald (ORCID: https://orcid.org/0009-0000-5507-7839)
- Nader Shaikh (ORCID: https://orcid.org/0000-0002-1602-343X)
- Sojin Lee
- Monika Johnson
- Max Homm
Institutions
- University of British Columbia (CA)
- University of Waterloo (CA)
- University of Pittsburgh (US)
- St. Joseph's Hospital (CA)
- Children's Hospital of Pittsburgh (US)
- McMaster University (CA)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s13073-025-01447-3
- Citations
- 11
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 14.90
Funders
- Government of Ontario
- Natural Sciences and Engineering Research Council of Canada
- Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases