Evaluation of Indoleamine 2,3-Dioxygenase (IDO) Expression in Osteosarcoma: Insights From a 10-Year Retrospective Cohort
Our comprehensive study findings indicate that most osteosarcoma patients do not exhibit expression of IDO. This absence of expression aligns with the characteristic "cold" tumor microenvironment observed in osteosarcoma. Further investigations are imperative to provide deeper insights into the intricacies of this immunomodulatory factor in the context of osteosarcoma.
Authors
- Aatif Amin (ORCID: https://orcid.org/0000-0002-5649-5554)
- Muhammad Jawad Hassan
- Shaarif Bashir (ORCID: https://orcid.org/0000-0002-6942-9046)
- Ali Sheikh
- Asim V. Farooq (ORCID: https://orcid.org/0000-0002-4309-3353)
- Muhammad Tahseen
- Munazza Fatima (ORCID: https://orcid.org/0000-0002-1005-9001)
- Kashif Asghar (ORCID: https://orcid.org/0000-0002-6855-5008)
- Umer Sheikh (ORCID: https://orcid.org/0000-0001-6305-2252)
Institutions
- University of Central Punjab (PK)
- Shaukat Khanum Memorial Cancer Hospital and Research Center (PK)
Publication Details
- Journal
- OncoTargets and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/ott.s494899
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58