Saikosaponin A Mediates the Anti-Acute Myeloid Leukemia Effect via the P-JNK Signaling Pathway Induced by Endoplasmic Reticulum Stress
SSA induces apoptosis in AML cells by activating the ERS-mediated p-JNK signaling pathway, exhibiting significant anti-AML effects both in vitro and in vivo, accompanied by a favorable safety profile.
Authors
- Panpan Yang (ORCID: https://orcid.org/0000-0002-7632-279X)
- Xue Bai (ORCID: https://orcid.org/0000-0002-5203-4080)
- Yoke Chin Chai (ORCID: https://orcid.org/0000-0001-9913-257X)
- Xiao-Hong Sun (ORCID: https://orcid.org/0000-0003-0572-2662)
- Hongxing Li (ORCID: https://orcid.org/0000-0001-6530-6711)
- Ya-Ming Xi (ORCID: https://orcid.org/0000-0002-7473-7561)
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s498458
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81