Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes
This was the largest coordinated effort to examine the presence of enterovirus RNA in the pancreas of organ donors with type 1 diabetes, using a multitude of assays. These findings are consistent with the notion that donors with type 1 diabetes and donors with islet autoantibodies may carry a low-grade enterovirus infection in the pancreas and lymphoid tissues.
Authors
- Ivan Gerling (ORCID: https://orcid.org/0000-0001-5097-6050)
- Jutta E. Laiho (ORCID: https://orcid.org/0000-0002-5443-4651)
- Heikki Hyöty (ORCID: https://orcid.org/0000-0003-0370-4145)
- Joseph F. Petrosino (ORCID: https://orcid.org/0000-0002-4046-6898)
- Alberto Pugliese (ORCID: https://orcid.org/0000-0002-7211-0319)
- Ashlie Renner
- Daniel Pearce Depledge (ORCID: https://orcid.org/0000-0002-4292-0599)
- Maarit Oikarinen (ORCID: https://orcid.org/0000-0003-1329-1508)
- Sofia Morfopoulou (ORCID: https://orcid.org/0000-0001-8181-4548)
- Sami Oikarinen (ORCID: https://orcid.org/0000-0003-3901-6774)
- Matthew C. Ross (ORCID: https://orcid.org/0000-0002-7621-8829)
- Antonio Toniolo (ORCID: https://orcid.org/0000-0003-3008-2126)
- Vincent Plagnol (ORCID: https://orcid.org/0000-0002-5597-9215)
- Judith Breuer (ORCID: https://orcid.org/0000-0001-8246-0534)
- Richard E. Lloyd (ORCID: https://orcid.org/0000-0002-6550-3237)
Institutions
- University of Insubria (IT)
- Tampere University of Applied Sciences (FI)
- University of Tennessee Health Science Center (US)
- Tampere University (FI)
- Baylor College of Medicine (US)
- City of Hope (US)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Fimlab (Finland) (FI)
- Genomics (United Kingdom) (GB)
- University College London (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1007/s00125-025-06359-w
- Citations
- 6
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 8.38
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Yrjö Jahnssonin Säätiö
- European Foundation for the Study of Diabetes
- Academy of Finland
- Päivikki ja Sakari Sohlbergin Säätiö
- Sigrid Juséliuksen Säätiö
- Tays
- Diabetestutkimussäätiö
- National Institutes of Health
- Seventh Framework Programme
- Pirkanmaan Rahasto