O25: Molecular mechanisms of FXTAS: A transcriptomic and epigenomic analysis of postmortem prefrontal cortex (AB-9) tissue
Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder affecting individuals with a premutation in the FMR1gene. This study aimed to elucidate the molecular mechanisms underlying FXTAS by examining gene expression and methylation profiles in the human brain.
Authors
- Xiao Lin
- Reymundo Lozano (ORCID: https://orcid.org/0000-0002-5616-5854)
- Dalila Pinto (ORCID: https://orcid.org/0000-0002-8769-0846)
- Ayako Kuno
Institutions
- Mount Sinai Hospital (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.102101
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00