O05: Implementation of pan-cancer universal germline testing as standard of care in an ethnically diverse, rural, underserved community oncology practice
Universal germline genetic testing (GGT) is increasingly utilized in precision cancer care, including access to approved therapeutics, clinical trial enrollment, early detection or prevention of future cancers, and testing of at-risk family members. There is limited data on this approach in patients from historically underrepresented and underserved populations receiving care at community practices. However, these patients may benefit the most from universal GGT as studies show current GGT guidelines miss ∼50% of patients with pathogenic germline variants (PGVs), particularly among Black/African-American patients.
Authors
- Rohan Nadkarni
- Edward D. Esplin (ORCID: https://orcid.org/0000-0001-9205-3756)
- Asutosh Gor
- Alimitha Kodali
- Jai V. Patel (ORCID: https://orcid.org/0000-0001-9248-0125)
- Niyati Nathwani
- Sarah M. Nielsen (ORCID: https://orcid.org/0000-0002-5916-6393)
- Viral Rabara
- Carson Lee Gallo
- Joseph M. DeSimone (ORCID: https://orcid.org/0000-0002-1764-8634)
- Sashi Naidu
- Brianna Bucknor
- Priya Mathur (ORCID: https://orcid.org/0000-0003-0378-7171)
- Kathryn E. Hatchell (ORCID: https://orcid.org/0000-0003-0849-7018)
- Kirstie Parnell
- Marian Łysiak
- Adara Hubbert
- Carlos Ortíz (ORCID: https://orcid.org/0000-0001-7983-7791)
- Laura McDonald (ORCID: https://orcid.org/0000-0001-9846-7626)
- Kashyap Patel (ORCID: https://orcid.org/0000-0002-4188-1794)
- S Kaw
- Zoe Gobeille
- Dabney Asmer
- Blake Koceja
Institutions
- Community Care (US)
- The US Oncology Network (US)
- Invitae (United States) (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.102030
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00